Chief investigators:
Timothy BREDY, David REUTENS, Pankaj SAH,
Functional MRI will be used to study contextual fear conditioning and extinction in humans. Individuals with different patterns of mesial temporal (hippocampal, amygdalar and parahippocampal) involvement will also be studied to tease out the differential impact of lesions in these structures and by systematically varying the cognitive, semantic and emotional components of context we plan to identify which contextual components should be manipulated to favour ‘good’ over ‘bad’ brain states for learning.